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Manuscript ID : JCHR-2106-1344 (R1) Visit : 61 Page: 599 - 607

10.22034/jchr.2021.1934089.1344

Article Type: Original Research

The Effects of Two Weeks Quercetin Supplementation in Adolescent Swimmer Girls on The Oxidative Stress and Inflammatory Mediator’s Response to Acute Swimming Session

Subject Areas : Journal of Chemical Health Risks

Masoumeh  Gholaman 1 (Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Maryam  Khodabakhsh Nokola 2 (Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Zahra  Ghorbani Ganjeh 3 (Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Shokoufeh  Sokhanvardastjerdi 4 (Department of Exercise Physiology, South Branch, Islamic Azad University, Tehran, Iran)
Mandana  Gholami 5 (Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Maryam  Kasiri 6 (Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)

Received: 2021-06-26 Accepted : 2021-11-06 Published : 2023-09-01

Keywords: Inflammation, Oxidative stress, Quercetin,

Abstract :

Quercetin could modulate the oxidative stress and inflammation, but its effects on exercise related oxidative stress and inflammation has attracted little attention. The present study conducted aimed to identify the effect of quercetin supplementation on oxidative stress and inflammatory mediator’s response following the acute swimming session. In semi-experimental study, the 20 trained swimmer girls (15.1±0.21 yrs old and BMI, 21.05±2.3 kg m-2) randomly allocated in two equal groups including quercetin (n= 10) and placebo (n= 10) groups. Subjects in quercetin group received 1000 mg quercetin daily for two weeks. Subsequently, participants completed the high intensity (>85% MHR) exhausting swimming session. In order to measurement the inflammatory (IL-6, CRP) and oxidative stress related markers, blood samples collected at the baseline, pre (after two-week quercetin supplementation) and immediately after completing the swimming session. Repeated-measures ANOVA test used for data analysis and significant levels considered at p<0.05. IL-6 significantly increased immediately after exercise in both groups (p<0.001), but IL-6 response to exercise in quercetin group was significantly less than placebo group (p<0.05). However, CRP don’t show significant changes (p>0.05). TAC doesn’t change, but significant increase in MDA, SOD, GPx and Catalase were observed in placebo and quercetin group immediately after swimming session (p<0.05) and MDA response to exercise session in quercetin group was significantly lower compared to placebo group (p<0.05). Quercetin modulated the IL-6 and MDA response after exhausting exercise and Quercetin can be considered as supplement for combating exercise induced inflammation and oxidative stress.

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